Experiences From a Desk-Based Programme  

Implementation of new endocrine disruption (ED) hazard classes in the CLP regulation and increasing regulatory scrutiny under chemicals, biocides and plant protection products regulations means ED assessment of substances/actives must be proactively addressed to ensure compliance and market access.

Combining expert judgement and key regulatory guidance documents, Blue Frog Scientific developed a pragmatic, stepwise approach to assessment of ED properties based on available or alternative information.

Dr. Bryony Ross, Principal Toxicologist and Head of Human Safety at Blue Frog Scientific helped develop and coordinate the company’s ED programme.

Bryony will be attending ToxExpo in San Diego to present a poster and disseminate Blue Frog Scientific’s experience in full. 

Poster Title

Experiences with a Desk-Based Programme to Determine Endocrine Disruption Potential According to the CLP Regulation

Wednesday 25th March - 1:45 - 4:15pm
ToxExpo, Hall B
Poster Board H584
Abstract Number 5035

Helping Clients Screen for EDs in Practice

Blue Frog Scientific’s approach to Endocrine Disruption Screening & Assessment is designed to allow rapid screening, which aids in the fulfilment of the requirements under the new CLP hazard classes, avoids additional animal testing, and aligns with state of the art of scientific regulatory science.

At the heart of the programme is a pragmatic, tiered framework that aligns closely with established guidance (notably ECHA/EFSA and OECD GD 150). The approach is deliberately stepwise: beginning with a Phase I screen based on available data and in silico profiling and progressing, where necessary, to a more detailed Phase II weight-of-evidence assessment. All data are organised according to the OECD Conceptual Framework levels, enabling efficient and transparent translation into a full ED assessment report in accordance with the ECHA/EFSA Guidance (2018), if required.

The approach leverages existing datasets – often heterogeneous and imperfect – to derive meaningful conclusions where possible, and a clear strategy outlining all possible next steps.

This structured flow of activities allows us to support pragmatic assessment of complex datasets. Most notably, in the case of borderline or complex datasets, where signals of endocrine activity exist but do not clearly meet classification criteria, the approach supports transparent conclusions (e.g. ED Category 2 or “data lacking”) alongside clear recommendations for follow-up.

Using this approach, we are able to generate robust, coherent strategy to support conclusions on ED which are in compliance with the new CLP requirements for hazard communication on endocrine disruption, and support longevity of registration for applicants. 

Download PDF of Poster: 

If you have interest in endocrine disruption, but can't be there on Wednesday, Bryony will be attending the conference and will be found at booth 2543. Or call or email and speak with Bryony directly anytime.