Endocrine disruption is now firmly on the regulatory agenda – and with the introduction of new hazard classes under CLP, many organisations are facing a difficult question:

How do you assess endocrine disruption robustly… when the data isn’t perfect?

At SETAC EU 2026, Marianne Matzke and colleagues from Blue Frog Scientific will present a practical, science-led answer.

Poster Presentation

“A Desk-Based Approach to Determine the New CLP Endocrine Disruption Hazard Classes”
Presentation ID: 6.04.P-Mo388
Blue Frog Scientific – Booth 79

A Smarter Way to Tackle Endocrine Disruption Under CLP

Regulatory expectations are increasing rapidly across:

• REACH (EU & UK).
• Biocidal Products Regulation (BPR).
• Plant Protection Products Regulation (PPPR).

At the same time, many datasets:

• Don’t meet modern GLP standards.
• Lack key endocrine endpoints.
• Rely heavily on vertebrate studies.
• Are incomplete or inconsistent.

This creates a real challenge making confident, defensible decisions with imperfect evidence.

A Structured, Pragmatic Approach

Marianne’s poster introduces a stepwise, desk-based framework that allows organisations to:

• Build a robust weight-of-evidence assessment.
• Align with OECD GD 150 and ECHA/EFSA guidance.
• Meet new CLP hazard classification requirements.
• Avoid unnecessary animal testing.
• Maintain regulatory compliance and market access.

As shown on the poster (top section and flow diagrams on page 1), the approach moves from:

• Literature search and data gathering.
• Screening and conceptual framework alignment.
• Targeted evaluation of endocrine activity and adversity.
• Full ED assessment and classification.
• From Screening to Decision-Making.

The methodology is not just theoretical – it’s designed for real regulatory workflows.

A case study in the poster demonstrates how:

• Legacy and limited datasets can still support conclusions.
• Mechanistic gaps can be addressed through read-across and in silico tools.
• A Category 2 endocrine disruptor classification can be justified despite uncertainties.

This is exactly the kind of pragmatic, defensible science regulators expect – and industry needs.

Key Takeaways

• Endocrine disruption assessment is becoming more complex, not less.
• A structured framework enables clarity from incomplete data.
• Integrating mechanistic understanding + weight of evidence is critical.
• In silico methods and read-across will play an increasing role in future assessments.
   

Meet the Blue Frog Team at SETAC EU 2026

If you’re working with complex or legacy datasets, ED classification under CLP, Biocides or plant protection products, substances with uncertain endocrine activity... attend Marianne’s poster to discuss how this approach can be applied to your substances.

Or come and meet the team at booth 79, and speak directly with our regulatory experts.

Download a copy of Marianne's poster here...